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GSH increases activation of cytotoxic T cells in vivo , and adequate functioning of T lymphocytes and other cells depends upon cellular supplies of cysteine (Edinger and Thompson, 2002

They might be taking a high dose on paper, but only a small fraction is surviving the "first-pass metabolism" in the liver and digestive system

[3] The same work profiled shifts in the cecal microbiome associated with treatment

3pgt: X Ji, J Blaszczyk, B Xiao, R ODonnell, X Hu, C Herzog, SV Singh & P Zimniak (1999) Structure and function of residue 104 and water molecules in the xenobiotic substrate-binding site in human glutathione S-transferase P1-1